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  • Researchers identify core genetic networks driving human embryonic stem cell behavior

    At the earliest stages of human embryonic development, a small collection of cells known as human embryonic stem cells (hESCs) orchestrates growth and differentiation, eventually giving rise to highly specialized human tissues. As pluripotent cells -- progenitors of every type of cell type in the body -- hESCs are of central interest to developmental and regenerative biologists. Many genes driving hESC functioning have previously been identified, but powerful tools that shed light on the interrelated activities of these genes have only emerged more recently. Researchers from Brigham and Women's Hospital and Harvard Medical School used genome-wide genetic screening to both over-express and inactivate ("knock out") tens of thousands of genes in hESCs. They uncovered key networks that simultaneously control pluripotency and readiness for cell death (apoptosis), helping to ensure optimal conditions for embryonic development. The study's findings, published in Genes and Development, offer new insights into cancer genetics and a novel approach for regenerative medicine research.

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  • Back and neck pain treatments range from self-care to surgery; prevention is key

    When back or neck pain strikes, normal activity is disrupted. Seeking relief for back or neck pain is one of the most common reasons people go to their health care provider or miss work.

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  • Best exercises for sciatica

    People with sciatica may find that certain exercises and stretches help bring relief from pain and tightness in the sciatic nerve and the surrounding area. Although sciatica generally resolves in time, these exercises may speed the healing process.

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  • Lower back pain now treated by implantable nerve stimulation device

    The recently approved ReActiv8 Implantable Neurostimulation system, now available at UCHealth, is a new option for patients with chronic low back pain.

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  • Muscle relaxants largely ineffective for low back pain

    Muscle relaxant drugs are largely ineffective for low back pain, despite being widely prescribed for this condition, suggests an analysis of the latest evidence published by The BMJ today.

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  • Generate looks to in-house stem cell manufacturing

    Generate Life Sciences is establishing a GMP facility in La Jolla, California that it says will enable end-to-end manufacturing of newborn stem cell biologics, bolstering supply and safeguarding clinical research.

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  • Is Walking Good for Sciatica?

    Whether you should walk and how much you should walk are questions to discuss with your doctor or physical therapist. The general view now is that movement and activity are a good thing for people with sciatica, as long as you walk correctly and are not increasing pain.

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  • Mayo Clinic Minute: Scoliosis is not just for kids

    Scoliosis is a condition that causes the spine to curve. It's frequently diagnosed in children—often during the growth spurt just before puberty. But it can happen in adults.

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  • Why Is My Sciatica Not Going Away?

    Sciatica is a condition caused by an irritation, inflammation, pinching, or compression of your sciatic nerve. It can lead to moderate-to-severe pain and weakness in your lower back, buttocks, and legs. Sciatica typically heals in 4 to 6 weeks, but for some people, it can last longer.

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  • Innovative Regenerative Medicine Therapies – Patient Safety Comes First

    The U.S. Food and Drug Administration continues to facilitate the development and availability of innovative medical products, such as regenerative medicine therapies, that have the potential to treat or even cure diseases or conditions for which few effective treatment options exist.

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